Player props have become one of baseball’s most entertaining ways to bet, offering value well beyond the moneyline, run line, or game total. Each day, this column highlights the best opportunities on the board — from strikeouts and hits to total bases and pitcher outs recorded — using matchup data, recent form, and betting trends to identify edges. Keep reading for the top MLB player prop picks for April 22. Also, make sure you check out our live VSiN programming for more. Our hosts and analysts will be all over the MLB, which is why it pays to be a VSiN Pro subscriber.

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Wednesday Player Prop Best Bets

Below you’ll find my official plays on the player prop market for Wednesday. These are the ones that make the VSiN Pro Picks page and count towards my season-long record. I’ll write three up per day but I’ll add additional ones in an “Additional Best Bets” section. That’s also where you’ll find any late adds to my card.

Trevor Story Over 1.5 Hits + Runs + RBIs (+111) vs. Yankees

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Yankees at Red Sox – 6:45 pm ET

Story has had a lousy season for Boston thus far, batting .189 through 23 games. However, the shortstop does have 17 RBIs, showing that he’s still capable of turning in some big performances. Well, at +111 odds to go Over 1.5 combined hits, runs, and RBIs, I think grabbing Story to have a productive day at the plate is worth it. Max Fried will be toeing the rubber for New York in this one, so the Yankees have their best available starter going. But it should be noted that Story is 5 for 19 with a double, two homers, and five RBIs against Fried in his career. He won’t be intimidated by this matchup. Story has also been a good hitter when facing southpaws throughout his career, plus he enjoys getting to hit in Fenway Park.

Matt Olson Over 1.5 Hits + Runs + RBIs (-140) vs. Nationals

Braves at Nationals – 6:45 pm ET

Olson has gone Over 1.5 combined hits, runs, and RBIs in eight consecutive games. He has also done so in 11 of the last 12 games. Olson is just scorching hot at the moment, and tonight’s total is up at 9.0. That said, I feel like riding the hot hand is a good move. Washington will also have a struggling starter on the mound, as Zack Littell is coming off a game in which he allowed eight earned runs on 11 hits in 4.0 innings of work. And while Olson hasn’t quite had much success against the righty in his career, I do think there’s a decent chance he changes that here. I’ll also note this: Olson averaged 2.8 HRR in games with totals of 9.0 or higher in 2025 when playing against right-handed starters.

Eduardo Rodriguez Over 16.5 Outs Recorded (-130 – 1.5 units) vs. White Sox

White Sox at Diamondbacks – 9:40 pm ET

Rodriguez has himself a golden opportunity to turn in a strong start tonight. This has been a really good start to the season for Rodriguez, who is 1-0 with a 1.96 ERA through four appearances. Well, in tonight’s game, Rodriguez is going up against a White Sox team that is tied for 20th in Major League Baseball in wRC+ (95) and sits in 29th in batting average (.218). And while Chicago has been much better against southpaws, I don’t see this being a rough matchup for Rodriguez. In fact, I think we’ll see the lefty go around 7.0 innings here, so I’m going bigger on this than I usually do.

Additional Best Bets

Brandon Williamson Over 3.5 Strikeouts (+118) vs. Rays

Eric Lauer Over 4.5 Strikeouts (-110) vs. Angels

Chad Patrick Over 4.5 Strikeouts (+125) vs. Tigers

Bryan Reynolds Over 0.5 Total Bases (-155 – 1.5 units) vs. Rangers

Tyler Mahle Over 4.5 Strikeouts (-106) vs. Dodgers

Noteworthy OptaAI Player Prop Edges

Check out the BRAND NEW OptaAI Player Props MLB pages for more of these! VSiN Pro subscribers can find 50+ player prop ideas on a daily basis! We’ll list the top edges in some of the biggest markets below, but there will always be a lot more to uncover on the pages themselves.

Anthony Kay Over 3.5 Strikeouts (+111) vs. Diamondbacks

Our OptaAI player prop projections have him going for 4.79 strikeouts, suggesting these odds should be -239 — a +23.1% edge to the Over.

Brice Matthews Over 0.5 Hits + Runs + RBIs (-149) vs. Guardians

Our OptaAI player prop projections have him finishing with 1.66 hits, runs, and RBIs, suggesting these odds should be -427 — a +21.2% edge to the Over.

Kerry Carpenter Over 1.5 Total Bases (+168) vs. Brewers

Our OptaAI player prop projections have him finishing with 1.94 total bases, suggesting these odds should be -136 — a +20.4% edge to the Over.

The post MLB Player Props Today: Top Picks for Wednesday, April 22 appeared first on VSiN.