Today we kick off the weekend with a loaded 15 game MLB slate to choose from. Let’s examine where smart money is leaning for a trio of matchups using our VSiN MLB Betting Splits, which are updated every 5 minutes and come directly from DraftKings and Circa Sports.

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4:10 p.m. ET: Washington Nationals at Chicago White Sox (-145, 8.5)

The White Sox (11-15) won last night’s Interleague series opener 5-4, coming through as -130 home favorites.

In this late afternoon rematch, the Nationals (11-16) tap righty Jake Irvin (1-3, 6.00 ERA) and the White Sox start lefty Noah Schultz (1-1, 3.86 ERA).

This line opened with Chicago listed as a -135 home favorite and Washington a +115 road dog.

Pros have laid the modest chalk with the White Sox at home, pushing Chicago up from -135 to -145.

At Circa, the White Sox are taking in only 57% of moneyline bets but 74% of moneyline dollars, a notable “low bets, higher dollars” sharp split in their favor from the wiseguys in the desert.

Non-division home favorites -150 or less coming off a win with line movement in their favor are 123-82 (60%) with a 7% ROI since 2025. When both teams are below .500, as is the case here, the home team coming off a win has gone 94-56 (63%) with a 3% ROI since 2025.

Saturday home favorites off a win are 17-8 (68%) with an 11% ROI this season. Interleague home favorites who won the series opener and are receiving line movement in their direction in the second game are 47-22 (68%) with a 9% ROI since 2025.

Washington has gone 1-3 in Irvin’s last four starts. He has posted a 6.63 ERA in those four starts, allowing 14 earned runs in 19 innings pitched.

4:10 p.m. ET: Minnesota Twins at Tampa Bay Rays (-135, 8.5)

The Rays (14-11) took last night’s series opener 6-2, cruising as -145 home favorites.

In this late afternoon rematch, the Twins (12-14) send out righty Bailey Ober (2-0, 4.15 ERA) and the Rays go with lefty Shane McClanahan (1-2, 5.00 ERA).

This line opened with Tampa Bay listed as a -125 home favorite and Minnesota a +105 road dog.

Wiseguys have pounced on the Rays laying short chalk at home, steaming Tampa Bay up from -125 to -135, with several shops even touching -140.

Sharps have also come down in support of the Rays run-line (-1.5 at +160), as Tampa Bay is receiving only 41% of spread bets but a hefty 75% of spread dollars at DraftKings, a notable “low bets, higher dollars” split in favor of the Rays winning by two runs or more.

Saturday home favorites off a win, like the Rays here, are 17-8 (68%) with an 11% ROI this season. Non-division home favorites -150 or less coming off a win with line movement in their favor are 123-82 (60%) with a 7% ROI since 2025.

Ober has a 6.75 ERA on the road compared to 3.68 at home this season.

The Rays are 6-4 at home this season. The Twins are 5-8 on the road.

7:10 p.m. ET: New York Yankees (-150, 9) at Houston Astros

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The Yankees (17-9) won last night’s series opener 12-4, taking care of business as -155 road favorites.

In tonight’s rematch, the Yankees hand the ball to lefty Ryan Weathers (1-2, 3.18 ERA) and the Astros (10-17) counter with righty Mike Burrows (1-3, 6.75 ERA).

This line opened with New York listed as a -145 road favorite and Houston a +125 home dog.

Sharps are riding the hot hand and have once again laid the chalk with the Yankees, driving New York up from -145 to -150, with some shops inching up to -155.

At Circa, New York is receiving 60% of moneyline bets and 81% of moneyline dollars, a notable “low bets, higher dollars” sharp split in their favor from the sharps in Vegas.

We’ve also seen sharp action back the Yankees on the run-line (-1.5 at +110), as the Bronx Bombers are taking in 75% of spread bets and 94% of spread dollars at Circa along with 73% of spread bets and 96% of spread dollars at DraftKings.

The Yankees have value as a non-division favorite, with the lack of familiarity benefiting the “better” team who is expected to win.

Weathers has been better on the road (2.08 ERA) than at home (3.38 ERA) this season.

Meanwhile, the Astros are just 1-4 in Burrows’ five starts this season. He has allowed 4 earned runs or more in three of his five starts.

New York has the far better bullpen as well, sporting a team ERA of 4.04 compared to 5.75 for Houston (2nd worst in MLB).

The post Top Picks from the MLB Betting Splits for Saturday April 25th appeared first on VSiN.