Seattle Seahawks at Arizona Cardinals

Kyler Murray (over 211.5 passing yards -113): Through three games this season, the Arizona Cardinals’ offense hasn’t exactly been among the NFL’s most prolific. They’ve maintained a fairly balanced run-pass approach, but with James Conner sidelined, they may need to lean more on the pass. Throughout Kyler Murray’s career in the NFC West, he’s faced the Seahawks 10 times, averaging 243.1 yards per game. He’s fallen short of this 211.5 mark in only two of those games—one of which saw him attempt just 18 passes, well below his 35.6 average against Seattle. Last season alone, Murray threw for 285 and 259 yards in the two matchups, so I expect a similar output in this one.

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Jaxon Smith-Njigba (under 81.5 receiving yards -110): Seahawks wide receiver Jaxon Smith-Njigba has gotten off to a blazing start, tallying 323 receiving yards on 22 catches with one touchdown in just three games. While impressive, he hasn’t fared as well against the Cardinals in the past, averaging 59 yards and 4.5 receptions per game. Granted, previous seasons featured a different quarterback and receiver dynamic, but Arizona will still need to game plan to limit Smith-Njigba, forcing Sam Darnold to look elsewhere in the passing attack.

Kenneth Walker III (anytime touchdown +105): Since the start of his career in 2022, Kenneth Walker III has been consistently effective against the Cardinals. While he hasn’t piled up touchdowns versus Arizona, he still averages over half a touchdown per game against them. This season, Walker already has three scores, two of which came last week against the Saints, and it’s clear offensive coordinator Klint Kubiak likes using him in the red zone. I’d expect that trend to continue in this matchup.