San Francisco 49ers vs. Los Angeles Rams

Matthew Stafford (under 31.5 pass attempts -112): Going into this game against the 49ers, the Rams have leaned heavily on Matthew Stafford’s arm, as he has averaged 34 pass attempts per game. One thing to note, however, is that last year Sean McVay’s scheme against the 49ers didn’t feature Stafford throwing as much, with 25 attempts in their first meeting and 27 in the second. This 49ers squad is also severely banged up on defense, most of it in the front seven, so I would anticipate a heavier rushing attack than usual for the Rams in this Week 5 matchup with San Francisco.

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Kyren Williams (over 68.5 rush yards -115): If the last prediction holds true with Matthew Stafford, it will play directly into this one for Kyren Williams. While Williams didn’t start strong in the first 2 games, he has bounced back in a big way, rushing for 94 yards in Week 3 and 77 yards in Week 4. The Rams have also leaned on him heavily against the 49ers—across 3 games, he has averaged 83 rushing yards on 22.3 attempts. The only game versus the 49ers where he didn’t surpass the 68.5-yard mark was his first meeting against them in 2023, when he had 14 carries for 52 yards. San Francisco also struggled badly against the run last week versus the Jaguars, allowing Travis Etienne Jr. to go for 124 yards on 19 carries.

Christian McCaffrey (over 16.5 rush attempts): There is still plenty of uncertainty around the quarterback position for the 49ers this week due to the turf toe injury Brock Purdy is dealing with. Even if Purdy is able to go, they will certainly lean heavily on McCaffrey’s shoulders. So far this season, McCaffrey has averaged 17.25 carries per game, with 22 in Week 1, 13 in Week 2, and 17 in both Week 3 and Week 4. As a 49er, McCaffrey has only faced the Rams twice, recording 18 carries and 20 carries in those respective games.